Conzelmann C, Groß R, Meister TL, Todt D, Krawczyk A, Dittmer U, Stenger S, Münch J, Steinmann E, Müller JA, Pfaender S
Journal
Pediatrics
Publication Date
10/1/2020
DOI Link
http://doi.org/10.1542/peds.2020-031690
Brief Summary
This research brief explores the efficacy of using holder pasteurization to inactive SARS-CoV-2 spiked into 5 samples of human milk. Holder pasteurization (heating to 63°C for 30 minutes) is a standard procedure used to inactivate viral and bacterial agents, while at the same time preserving many beneficial and protective effects of human breast milk. It found that infectivity of all 5 SARS-CoV-2 isolates was completely eliminated by the treatment.
Abstract
No abstract
Section
Pediatrics
Topic
Breastfeeding
Vertical transmission
Level of Evidence
Level 4- Uncontrolled Cohort, Case Series, Consensus Panel
Daviet F, Guervilly C, Baldesi O, Bernard-Guervilly F, Pilarczyk E, Genin A, Lefebvre L, Forel JM, Papazian L, Camoin-Jau L
Journal
Circulation
Publication Date
9/1/2020
DOI Link
doi.org/10.1161/CIRCULATIONAHA.120.049015
Brief Summary
This is a controlled cohort study evaluating the incidence of HIT in patients with COVID-19 induced ARDS. The occurrence of HIT was ten fold greater in the COVID-19 cohort. The author speculates that the higher prevalence of HIT in these patients could be explained by exacerbated immune reactions, however, the pathophysiology of an increased thrombosis risk in this population is not yet understood and will require additional research for further clarification.
Abstract
Section
Hematology
Cardiology
Topic
Thrombosis
Anticoagulation
ARDS
Level of Evidence
Level 3- Case Control, Retrospective Cohort, Systematic Review
Journal Impact Factor
21.054
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Pasteurization Inactivates SARS-CoV-2 Spiked Breast Milk.
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Title
Pasteurization Inactivates SARS-CoV-2 Spiked Breast Milk.
Author
Conzelmann C, Groß R, Meister TL, Todt D, Krawczyk A, Dittmer U, Stenger S, Münch J, Steinmann E, Müller JA, Pfaender S
This research brief explores the efficacy of using holder pasteurization to inactive SARS-CoV-2 spiked into 5 samples of human milk. Holder pasteurization (heating to 63°C for 30 minutes) is a standard procedure used to inactivate viral and bacterial agents, while at the same time preserving many beneficial and protective effects of human breast milk. It found that infectivity of all 5 SARS-CoV-2 isolates was completely eliminated by the treatment.
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Abstract
No abstract
Section
Pediatrics
Topic
Breastfeeding
Vertical transmission
Level of Evidence
Level 4- Uncontrolled Cohort, Case Series, Consensus Panel